Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action.

نویسندگان

  • Hui Ming Ge
  • Wei Yan
  • Zhi Kai Guo
  • Qiong Luo
  • Rui Feng
  • Le Yun Zang
  • Yan Shen
  • Rui Hua Jiao
  • Qiang Xu
  • Ren Xiang Tan
چکیده

Precursor-fed cultivation of endophytic Chaetomium globosum 1C51 afforded nine novel "unnatural" halogenated chaetoglobosins including those with more preferable immunosuppressive activity.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Novel soraphens from precursor directed biosynthesis.

Six novel halogenated soraphen analogues have been isolated from the wild-type producing organism using precursor directed biosyntheses; the best 'delivery vehicle' for the novel starter acids was cinnamate but ortho substituents were not tolerated by the soraphen PKS.

متن کامل

Bioactive metabolites from Stenocarpella maydis, a stalk and ear rot pathogen of maize.

Stenocarpella maydis is a fungal pathogen of major importance that causes a dry-rot of maize ears and is associated with a neuromycotoxicosis in cattle grazing harvested maize fields in southern Africa and Argentina. In an effort to investigate the potential roles of S. maydis metabolites in the fungal disease cycle, ethyl acetate extracts of solid-substrate fermentations of several S. maydis i...

متن کامل

Deep dermatophytosis in a patient with Rheumatoid Arthritis on immunosuppressive drugs: A case report

Dermatophyte infections are one of the most common superficial fungal infections. However dermatophytes invade subcutaneous tissues rarely. We report herein a 65 year-old woman who was as a known case of rheumatoid arthritis (For 10 years) and taking immunosuppressive drugs, presented with multiple nodules and sinuses in the knee area. Histopathologic studies revealed PAS positive granulomas an...

متن کامل

Review of Anti-inflammatory and Immunosuppressive Drugs Used in COVID-19 Epidemic

Introduction: Immunosuppressive drugs are classified into different groups depending on the mechanism of action and are used in the control of acute and chronic inflammatory disorders. Considering the possibility of severe inflammatory complications such as acute respiratory failure and cytokine storm in the patients with COVID-19, there is a need to review the updated data on the effectiveness...

متن کامل

Vaticaffinol, a resveratrol tetramer, exerts more preferable immunosuppressive activity than its precursor in vitro and in vivo through multiple aspects against activated T lymphocytes.

In the present study, we aimed to investigate the immunosuppressive activity of vaticaffinol, a resveratrol tetramer isolated from Vatica mangachapoi, on T lymphocytes both in vitro and in vivo, and further explored its potential molecular mechanism. Resveratrol had a wide spectrum of healthy beneficial effects with multiple targets. Interestingly, its tetramer, vaticaffinol, exerted more inten...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Chemical communications

دوره 47 8  شماره 

صفحات  -

تاریخ انتشار 2011